Ovine progressive pneumonia virus infection rate and incidence of genetic susceptibility diplotype in North Dakota sheep flocks
نویسندگان
چکیده
The objectives for the project were to determine the incidence of sheep serologically positive for ovine progressive pneumonia virus (OPPV) and frequency of diplotypes known to affect OPPV susceptibility in sheep. Of the 12 flocks tested, 1/3 had a high incidence of OPPV positive sheep and 2/3 had a low incidence or no sheep test positive for OPPV. Sheep with both copies of the more favorable diplotype “1” had a lower incidence of OPPV positive sheep than sheep with at least one unfavorable haplotype “2 or 3”. Younger ewes had a lower OPPV infection rate.
منابع مشابه
Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock
Small ruminant lentivirus (SRLV), also called ovine progressive pneumonia virus or maedi-visna, is present in 24% of US sheep. Like human immunodeficiency virus, SRLV is a macrophage-tropic lentivirus that causes lifelong infection. The production impacts from SRLV are due to a range of disease symptoms, including pneumonia, arthritis, mastitis, body condition wasting and encephalitis. There is...
متن کاملEffects of TMEM154 haplotypes 1 and 3 on susceptibility to ovine progressive pneumonia virus following natural exposure in sheep.
Small ruminant lentiviruses (SRLV) adversely affect production and well-being of sheep and goats throughout much of the world. The SRLV, including ovine progressive pneumonia virus (OPPV) in North America, cause lifetime infections, and management procedures to eradicate or reduce disease prevalence are costly. Variants of ovine transmembrane protein 154 gene (TMEM154) affect susceptibility to ...
متن کاملIncidence of infection in 39-month-old ewes with TMEM154 diplotypes "1 1," "1 3," and "3 3" after natural exposure to ovine progressive pneumonia virus.
Production and well-being of sheep and goats in many countries are harmfully impacted by small ruminant lentiviruses (SRLV) that cause incurable, progressive diseases. Susceptibility to ovine progressive pneumonia virus (OPPV), the North American form of SRLV, is influenced by variants of the ovine transmembrane protein 154 gene (TMEM154). The experimental objective was to estimate additive and...
متن کاملGenetic Testing for TMEM154 Mutations Associated with Lentivirus Susceptibility in Sheep
In sheep, small ruminant lentiviruses cause an incurable, progressive, lymphoproliferative disease that affects millions of animals worldwide. Known as ovine progressive pneumonia virus (OPPV) in the U.S., and Visna/Maedi virus (VMV) elsewhere, these viruses reduce an animal's health, productivity, and lifespan. Genetic variation in the ovine transmembrane protein 154 gene (TMEM154) has been pr...
متن کاملDevelopment and validation of an ovine progressive pneumonia virus quantitative PCR.
Ovine progressive pneumonia virus (OPPV) infects at least one sheep in 81% of U.S. sheep flocks, as determined by serology, and can cause viral mastitis, arthritis, dyspnea, and cachexia. Diagnostic tests that quantify OPPV proviral load in peripheral blood leukocytes (PBL) provide an additional method for identification of infected sheep and may help to further understanding of the pathogenesi...
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